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Adaptive evolution of centromere proteins in plants and animals

2019-12-12 17:46

The proteins and chromatin at the centromere form a unique site for kinetochore attachment and allow the cell to sense and correct errors during chromosome segregation.Meiotic drive model of centromere evolution. The consensus DNA sequences and their binding proteins are recognizably similar in yeasts as distantly related as Candida glabrata and Kluyveromyces lactis, which have greater average divergence from budding yeast in protein sequences than mammals have from fish adaptive evolution of centromere proteins in plants and animals

May 03, 2012 In animal lineages, on a specieswide scale, centromere size does appear to correlate with chromosome size. Using broadly reactive antikinetochore (CREST) antisera, previous authors showed that species with few large chromosomes have larger centromeres than species with numerous small chromosomes (Cherry et al. 1989 ).

Adaptive evolution of centromere proteins in plants and animals free

Aug 31, 2004 The nucleosomes of centromeres are characterized by a special H3like histone (CenH3), which evolves rapidly and adaptively in Drosophila and Arabidopsis. Most plant, animal and fungal centromeres also bind a large protein, centromere protein C (CENPC), that is characterized by a single 24 aminoacid motif (CENPC motif).

(1999). EN: A maize homolog of mammalian CENPC is a constitutive component of the inner kinetochore. Plant Cell (1995). Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENPC.

In maize, sugarcane, evolving in multiple lineages of both plants and animals, a and Sorghum we detected negative selection for exons 912, feature that had been previously shown for some CenH3s. but in the more recent duplication of exons 9 and 10 in Thus, the occurrence of adaptive evolution appears to be a wheat and barley we detected positive selection in a region general feature of proteins that bind to complex centro

Most plant, animal and fungal centromeres also bind a large protein, centromere protein C (CENPC), that is characterized by a single 24 aminoacid motif (CENPC motif). Results Whereas we find no evidence that mammalian CenH3 (CENPA) has been evolving adaptively, mammalian CENPC proteins contain adaptively evolving regions that overlap with regions of DNAbinding activity.

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In plants we find that CENPC proteins have complex duplicated regions, with conserved amino and carboxyl termini that are dissimilar in sequence to their counterparts in animals and fungi.

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