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Interferon gamma receptor beta chain

2019-12-05 16:14

Bax is a proapoptotic protein that mediates intrinsic celldeath signaling. Using a yeastbased functional screening approach, we identified interferon gamma receptor beta chain (IFNR2) as a new Bax suppressor. IFNR2 is a component of the IFN receptor complex along with the IFNR alpha chainJul 14, 1995 The IFNgammainducible signal transducing factor (STFIFN gamma) was activated in murine TH2 but not in TH1 cell clones, because in the latter the second chain of the IFNgamma receptor (accessory factor 1 or IFNgamma R beta) was absent. interferon gamma receptor beta chain

identified interferon gamma receptor beta chain (IFNR2) as a new Bax suppressor. IFNR2 is a component of the IFN receptor complex along with the IFNR alpha chain (IFNR1). Upon IFN binding, a conformational change in the receptor complex occurs that activates the Jak2STAT1 signaling cascade. We found

Interferon gamma receptor beta chain free

Michael F. Murray, in Emery and Rimoin's Principles and Practice of Medical Genetics, 2013. Interferon Gamma Receptor Genes (IFNGR1 AND IFNGR2)The interferon gamma receptor (IFNR) is expressed in all nucleated cells as a tetramer composed of two IFNR1 and two IFNR2 subunits (130). IFNGR1 maps to 6q2324, and IFNGR2 maps to 21q.

Interferongamma receptor beta chain has a predicted molecular weight of 38 kDa, however it is extensively glycosylated and has been shown to run in the 49 kDa region (SwissProt data). The bands present at 48 kDa are representative of the protein minus its 27 amino acid signal peptide.

The human interferongamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. [2 [3 In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases

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The gene IFNGR1 encodes IFNR1, which is the ligandbinding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages. IFNGR2, encodes IFNR2, the nonligandbinding partner of the heterodimeric receptor. Interactions. Interferon gamma receptor 1 has been shown to interact with Interferongamma.

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